synthesis and evaluation of the anxiolytic activity of some phthalimide derivatives in mice model of anxiety

Authors

farshid hassanzadeh department of medicinal chemistry, isfahan university of medical sciences, isfahan, iran. isfahan pharmaceutical sciences research center, faculty of pharmacy, isfahan university of medical sciences, isfahan, iran.

mohammad rabbani department of medicinal chemistry, isfahan university of medical sciences, isfahan, iran. isfahan pharmaceutical sciences research center, faculty of pharmacy, isfahan university of medical sciences, isfahan, iran.

ghadam ali khodarahmi department of medicinal chemistry, isfahan university of medical sciences, isfahan, iran. isfahan pharmaceutical sciences research center, faculty of pharmacy, isfahan university of medical sciences, isfahan, iran.

mehrnoosh moosavi department of medicinal chemistry, isfahan university of medical sciences, isfahan, iran.

abstract

the aim of the present study was to synthesis a series of phthalimides based on our previous works and examine their anxiolytic properties. using a three steps process, phthalimides were prepared from the corresponding di-methyl phthalate derivatives. phthalic anhydride was nitrated to produce 3-nitrophthalic acid. ring closer of either 3-nitrophthalic acid or di-methyl phthalate with urea were carried out in reflux condition. final compounds were prepared by base catalyzed condensation of 4-methylbenzoyl chloride, benzoyl chloride and benzyl chloride with the resulting imides. from the tested compounds, only n-benzoyl 3-nitro-phthalimide was shown to produce anxiolytic activity by increasing the number of entries and time spent in open arms at 10 mg/kg.

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Synthesis and Evaluation of the Anxiolytic Activity of Some Phthalimide Derivatives in Mice Model of Anxiety

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Journal title:
the iranian journal of pharmaceutical research

جلد ۱۱، شماره ۱، صفحات ۱۰۹-۱۱۵

Keywords
[ ' p h t h a l i m i d e ' , 3 , ' n i t r o p h t h a l i m i d e ' , ' e l e v a t e d p l u s ' , ' m a z e ' , ' a n x i e t y ' ]

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